Neonatal-Onset Multisystem Inflammatory Disorder
نویسندگان
چکیده
منابع مشابه
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition.
BACKGROUND Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation. Many patients have mutations in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene, encoding cryopyrin, a protein that regulates inflammation. METHODS We selected 18 patients with neonatal-onset multisyst...
متن کاملSafe and effective canakinumab-treatment of neonatal onset multisystem inflammatory disease (NOMID)/ chronic infantile neurologic cutaneous and articular (CINCA)
Introduction NOMID/CINCA is the most severe phenotype of cryopyrin-associated periodic syndrome (CAPS), characterized by persistence of inflammation-mediated symptoms and overproduction of interleukin (IL)-1b, associated with significant morbidity, if untreated. In CAPS-patients early initiation of anti-IL1b-treatment appears to prevent severe disease sequelae. However, canakinumab as a 1-line ...
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 2005
ISSN: 0003-987X
DOI: 10.1001/archderm.141.2.248